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スタッフ紹介

業績

2024年

原著論文（欧文）

  • Ito S, Misaki T, Nagasawa Y, Nomura R, Naka S, Fukunaga A, Matsuoka D, Matayoshi S, Matsumoto-Nakano M and Nakano K, Porphyromonas gingivalis infection in the oral cavity is associated with elevated galactose-deficient IgA1 and increased nephritis severity in IgA nephropathy. Clin Exp Nephrol. 2024, 28(3):192-200.

  • Shojima K, Mori T, Wada Y, Kusunoki H, Tamaki K, Matsuzawa R, Nagai K, Goto M, Tabuchi T, Nagasawa Y and Shinmura K, Factors contributing to subjective well-being and supporting successful aging among rural Japanese community-dwelling older adults: A cross-sectional and longitudinal study. Geriatr Gerontol Int. 2024. Online ahead of print. 

  • Nagai K, Koki Akai, Itaru Tanaka, Haruhi Shimizu, Matsuzawa R, Tamaki K, Kusunoki H, Wada Y, Shotaro Tsuji, Kana Hashimoto and Shinmura K, Do the physical activity questions in the Japanese version of the Cardiovascular Health Study criteria truly reflect a decline in physical activity? Geriatr Gerontol Int. 2024, 24(2):240-242.

2023年

原著論文（欧文）

  • Nagai K, Komine T, Ikuta M, Gansa M, Matsuzawa R, Tamaki K, Kusunoki H, Wada Y, Tsuji S, Sano K and Shinmura K, Decline of instrumental activities of daily living is a risk factor for nutritional deterioration in older adults: a prospective cohort study. BMC Geriatr. 2023, 23(1):480.

  • Wada Y, Shojima K, Tamaki K, Mori T, Kusunoki H, Onishi M, Tsuji S, Matsuzawa R, Nagai K, Sano K, Hashimoto K, Goto M, Nagasawa Y and Shinmura K, Association Between Timed Up-and-Go Test and Future Changes in the Frailty Status in a Longitudinal Study of Japanese Community-Dwelling Older Adults. Clin Interv Aging. pages 1191-1200. 

  • Kimura T and Shinmura K, Questionnaire survey of geriatricians and primary care physicians' approaches to treating older patients with multimorbidity. Geriatr Gerontol Int. 29(5):701-707. doi: 10.1097/PHH.0000000000001755.

  • Shojima K, Kobayashi T and Tabuchi T, Impact of the COVID-19 pandemic on influenza vaccination uptake and predictors of influenza vaccination in Japan: a cross-sectional study. J. Public Health Manag Pract. Online ahead of print.

  • Kusunoki H, Ekawa K, Kato N, Yamasaki K, Motone M, Shinmura K, Yoshihara F and Shimizu H. Association between oral frailty and cystatin C-related indices-A questionnaire (OFI-8) study in general internal medicine practice. PLoS One. 2023 Apr 24;18(4):e0283803. doi: 10.1371/journal.pone.0283803. eCollection 2023.

  • Imano N, Shojima K, Tamaki K and ShinmuraK, Estrogen contributes to the sex difference in the occurrence of senescence-related T cells during the development of visceral adipose tissue inflammation, Am. J. Physiol Heart Circ. Physiol. 2023 Mar 17. doi: 10.1152/ajpheart.00469.2022. Online ahead of print.

  • Takahashi Y, Morales Valencia M, Yu Y, Ouchi Y, Takahashi K, Shokhirev MN, Lande K, Williams AE, Fresia C, Kurita M, Hishida T, Shojima K, Hatanaka F, Nuñez-Delicado E, Esteban CR and Izpisua Belmonte JC. Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice. Cell. 2023 Feb 2. doi: 10.1016/j.cell.2022.12.047. Online ahead of print.

総説（欧文）

  • Nagasawa Y, Yamazaki H, Shojima K and Shinmura K, Appropriate exercise might have some benefits for both mothers and their babies via epigenesis. Hypertens Res. 2023 Jan 13. doi: 10.1038/s41440-022-01166-x. Online ahead of print.

総説（和文）

  • 新村 健. 【総合診療と老年医学】総合診療の立場からの高齢者医療　総合診療専門医と老年科専門医との理想的な連携. Geriatric Medicine, 2023, 61(2):157-160.

2022年

原著論文（欧文）

  • Nomura R, Nagasawa Y, Misaki T, Ito S, Naka S, Okunaka M, Watanabe M, Tsuzuki K, Matsumoto-Nakano M and Nakano K. Distribution of periodontopathic bacterial species between saliva and tonsils. Odontology. 2022 Dec 16. doi: 10.1007/s10266-022-00776-8. Online ahead of print.

  • Iijima H, Tada T, Hashimoto M, Nishimura T, Kiriki M, Higashiura A, Iwasaki A, Honda M, Nagasawa Y and Yamakado K. Utility of ultrasonography for predicting indications for tolvaptan in patients with autosomal dominant polycystic kidney disease. J Med Ultrason (2001). 2022 Nov 5. doi: 10.1007/s10396-022-01261-z. Online ahead of print.

  • Arai T, Kanazawa H, Kimura K, Munakata M, Yamakawa H, Shinmura K, Yuasa S, Sano M and Fukuda K, Upregulation of neuropeptide Y in cardiac sympathetic nerves induces stress (Takotsubo) cardiomyopathy. Front Neurosci. 2022 Nov 3;16:1013712. doi: 10.3389/fnins.2022.1013712. eCollection 2022.

  • Naka S, Matsuoka D, Goto K, Misaki T, Nagasawa Y, Ito S, Nomura R, Nakano K and Matsumoto-Nakano M. Cnm of Streptococcus mutans is important for cell surface structure and membrane permeability. Front Cell Infect Microbiol. 2022 Sep 13;12:994014. doi: 10.3389/fcimb.2022.994014. eCollection 2022.

  • Misaki T, Naka S, Nagasawa Y, Matsuoka D, Ito S, Nomura R, Matsumoto-Nakano M and Nakano K, Simultaneous Presence of Campylobacter rectus and Cnm-Positive Streptococcus mutans in the Oral Cavity Is Associated with Renal Dysfunction in IgA Nephropathy Patients: 5-Year Follow-Up Analysis. Nephron. 2022 Aug 23:1-10. doi: 10.1159/000525511. Online ahead of print.

  • Mori T, Nagai K, Tamaki K, Kusunoki H, Wada Y, Tsuji S, Matsuzawa R, Sano K, Amano M and Shinmura K, Impact of quality of life on future frailty status of rural Japanese community-dwelling older adults. Exp Gerontol. 2022 Oct 15;168:111930. doi: 10.1016/j.exger.2022.111930. Epub 2022 Aug 17.

  • Yamamoto R, Imai E, Maruyama S, Yokoyama H, Sugiyama H, Takeda A, Tsukamoto T, Uchida S, Tsuruya K, Shoji T, Hayashi H, Akai Y, Fukunaga M, Konta T, Nishio S, Goto S, Tamai H, Nagai K, Katafuchi R, Masutani K, Wada T, Nishino T, Shirasaki A, Sobajima H, Nitta K, Yamagata K, Kazama JJ, Hiromura K, Yasuda H, Mizutani M, Akahori T, Naruse T, Hiramatsu T, Morozumi K, Mimura T, Saka Y, Ishimura E, Hasegawa H, Ichikawa D, Shigematsu T, Sato H, Narita I and Isaka Y; Japan Nephrotic Syndrome Cohort Study investigators (including Nagasawa Y). Time to remission of proteinuria and incidence of relapse in patients with steroid-sensitive minimal change disease and focal segmental glomerulosclerosis: the Japan Nephrotic Syndrome Cohort Study. J Nephrol. 2022 May;35(4):1135-1144. doi: 10.1007/s40620-022-01279-z. Epub 2022 Apr 2.

  • Kusunoki H, Hasegawa Y, Tsuji S, Wada Y, Tamaki K, Nagai K, Mori T, Matsuzawa R, Kishimoto H, Shimizu H and Shinmura K, Relationships between cystatin C and creatinine-based eGFR with low tongue pressure in Japanese rural community-dwelling older adults. Clin Exp Dent Res. 2022 Oct;8(5):1259-1269. doi: 10.1002/cre2.619. Epub 2022 Jun 24.

  • Kusunoki H, Tabara Y, Tsuji S, Wada Y, Tamaki K, Nagai K, Itoh M, Sano K, Amano M, Maeda H, Sugita H, Hasegawa Y, Kishimoto H, Shimomura S, Igase M and Shinmura K, Estimation of Muscle Mass Using Creatinine/Cystatin C Ratio in Japanese Community-Dwelling Older People. J Am Med Dir Assoc. 2022 May;23(5):902.e21-902.e31. doi: 10.1016/j.jamda.2021.07.029. Epub 2021 Aug 23.

  • Saito S, Nakao Y, Hasegawa Y, Nagai K, Sano K, Uchiyama Y, Kishimoto H, Shinmura K and Domen K, Relationship between Rate of Force Development of Tongue Pressure and Physical Performance. J Clin Med. 2022 Apr 22;11(9):2347. doi: 10.3390/jcm11092347.

  • Marito P, Hasegawa Y, Tamaki K, Sta Maria MT, Yoshimoto T, Kusunoki H, Tsuji S, Wada Y, Ono T, Sawada T, Kishimoto H and Shinmura K. The Association of Dietary Intake, Oral Health, and Blood Pressure in Older Adults: A Cross-Sectional Observational Study. Nutrients. 2022 Mar 17;14(6):1279. doi: 10.3390/nu14061279.

総説（欧文）

  • Nagasawa Y, Misaki T, Ito S, Naka S, Wato K, Nomura R, Matsumoto-Nakano M and Nakano K. Title IgA Nephropathy and Oral Bacterial Species Related to Dental Caries and Periodontitis. Int J Mol Sci. 2022 Jan 10;23(2):725. doi: 10.3390/ijms23020725.

原著論文（和文）

  • 原山 茉優, 永井 宏達, 大川 夏実, 佐野 恭子, 楠 博, 玉城 香代子, 和田 陽介, 辻 翔太郎, 新村 健. 地域在住高齢者における身体活動量とアパシーの関連. 日本老年医学会雑誌, 2022;59(4):483-490.

総説（和文）

  • 楠 博, 田原 康玄, 新村 健. 日本人地域在住高齢者におけるクレアチニン/シスタチンC比を用いた筋肉量の推算. 兵庫医科大学医学会雑誌, 2022, 46(2):65-69.

  • 新村 健. 心臓老化とアンチエイジング医学 - Cardiac aging and anti-aging medicine-. アンチ・エイジング医学, 2022,18(3):186-191.

  • 長谷川 陽子, 永井 宏達, 辻 翔太郎, 玉岡 丈二, 澤田 隆, 小野 高裕, 岸本 裕充, 新村 健. 引きこもり予防に口腔機能維持は寄与するのか? 8020: はち・まる・にい・まる. 2022, 21:156-159.

  • 楠 博, 長澤 康行, 山崎 博充, 元根 正晴, 志水 秀郎, 新村 健. 総合診療の場で原発性アルドステロン症(PA)のスクリーニング、診断をする意義. 日本病院総合診療医学会雑誌. 2022, 18(3):182-189.

  • 新村 健. 実地医家が知っておくべき臨床栄養学　高齢者の栄養管理. 日本臨床内科医会会誌. 2022, 36(5):264-270.

2021年

原著論文（欧文）

  • Nagasawa Y, Nomura R, Misaki T, Ito S, Naka S, Wato K, Okunaka M, Watabe M, Fushimi K and Tsuzuki K, Relationship between IgA Nephropathy and Porphyromonas gingivalis; Red Complex of Periodontopathic Bacterial Species. Int J Mol Sci. 2021 Dec 1;22(23):13022. doi: 10.3390/ijms222313022.

  • Yan X, Imano N, Tamaki K, Sano M and Shinmura K, The effect of caloric restriction on the increase in senescence-associated T cells and metabolic disorders in aged mice. PLoS One. 2021 Jun 18;16(6):e0252547. doi: 10.1371/journal.pone.0252547. eCollection 2021.

  • Kusunoki H, Iwashima Y, Kawano Y, Ohta Y, Hayashi SI, Horio T, Shinmura K, Ishimitsu T and Yoshihara F. Associations Between Arterial Stiffness Indices and Chronic Kidney Disease Categories in Essential Hypertensive Patients. Am J Hypertens. 2021 May 22;34(5):484-493. doi: 10.1093/ajh/hpaa163.

  • Komatsu R, Nagai K, Hasegawa Y, Okuda K, Okinaka Y, Wada Y, Tsuji S, Tamaki K, Kusunoki H, Kishimoto H and Shinmura K. Association between Physical Frailty Subdomains and Oral Frailty in Community-Dwelling Older Adults. Int J Environ Res Public Health. 2021 Mar 12;18(6):2931. doi: 10.3390/ijerph18062931.

  • Nagai K, Matsuzawa R, Wada Y, Tsuji S, Itoh M, Sano K, Amano M, Tamaki K, Kusunoki H and Shinmura K, Impact of Isotemporal Substitution of Sedentary Time With Physical Activity on Sarcopenia in Older Japanese Adults. J Am Med Dir Assoc. 2021 Apr;22(4):876-878. doi: 10.1016/j.jamda.2021.02.007. Epub 2021 Mar 12.

総説（欧文）

  • 楠 博, 新村 健. 【老化と慢性炎症】循環器疾患における老化と慢性炎症. 別冊Bio Clinica: 慢性炎症と疾患. 2021, 10(2):73-77.

  • 新村 健. 【日本における高齢者コホート研究の成果と現状】FESTA 研究. 老年内科, 2021;4(4):400-404.

2020年

原著論文（欧文）

  • Hasegawa Y, Sakuramoto-Sadakane A, Nagai K, Tamaoka J, Oshitani M, Ono T, Sawada T, Shinmura K and Kishimoto H, Does Oral Hypofunction Promote Social Withdrawal in the Older Adults? A Longitudinal Survey of Elderly Subjects in Rural Japan. Int J Environ Res Public Health. 2020 Nov 30;17(23):8904. doi: 10.3390/ijerph17238904.

  • Tsuji S, Shinmura K, Nagai K, Wada Y, Kusunoki H, Tamaki K, Ito M, Sano K, Amano M, Hasegawa Y, Kishimoto H, Maruo K, Iseki T and Tachibana T, Low back pain is closely associated with frailty but not with sarcopenia: Cross-sectional study of rural Japanese community-dwelling older adults. Geriatr Gerontol Int. 2021 Jan;21(1):54-59. doi: 10.1111/ggi.14100. Epub 2020 Nov 27.

  • Kusunoki H, Tsuji S, Kusukawa T, Wada Y, Tamaki K, Nagai K, Itoh M, Sano K, Amano M, Maeda H, Sugita H, Hasegawa Y, Kishimoto H, Shimomura S and Shinmura K, Relationships between cystatin C- and creatinine-based eGFR in Japanese rural community- dwelling older adults with sarcopenia. Clin Exp Nephrol. 2021 Mar;25(3):231-239. doi: 10.1007/s10157-020-01981-x. Epub 2020 Oct 22.

  • Nagai K, Tamaki K, Kusunoki H, Wada Y, Tsuji S, Itoh M, Sano K, Amano M, Hayashitani S, Yokoyama R, Yonezawa R, Kamitani T and Shinmura K, Physical frailty predicts the development of social frailty: a prospective cohort study. BMC Geriatr. 2020 Oct 14;20(1):403. doi: 10.1186/s12877-020-01814-2.

  • Yamamoto T, Endo J, Kataoka M, Matsuhashi T, Katsumata Y, Shirakawa K, Isobe S, Moriyama H, Goto S, Shimanaka Y, Kono N, Arai H, Shinmura K, Fukuda K and Sano M, Palmitate induces cardiomyocyte death via inositol requiring enzyme-1 (IRE1)-mediated signaling independent of X-box binding protein 1 (XBP1), Biochem Biophys Res Commun. 2020 May 21;526(1):122-127. doi: 10.1016/j.bbrc.2020.03.027. Epub 2020 Mar 19.

  • Hasegawa Y, Sakuramoto-Sadakane A, Yoshida M, Yoshikawa M, Nozaki S, Hikasa S, Horii N, Sugita H, Ono T, Shinmura K and Kishimoto H, Basic survey for the prevention of intraoral residual medication in older adults: A pilot study, Gerodontology. 2020 Mar;37(1):93-96. doi: 10.1111/ger.12441. Epub 2019 Nov 20.

2019年

原著論文（欧文）

  • Hasegawa Y, Horii N, Sakuramoto-Sadakane A, Nagai K, Ono T, Sawada T, Shinmura K and Kishimoto H, Is a History of Falling Related to Oral Function? A Cross-Sectional Survey of Elderly Subjects in Rural Japan, Int J Environ Res Public Health. 2019 Oct 11;16(20):3843. doi: 10.3390/ijerph16203843.

  • Yamamoto T, Endo J, Kataoka M, Matsuhashi T, Katsumata Y, Shirakawa K, Yoshida N, Isobe S, Moriyama H, Goto S, Yamashita K, Ohto-Nakanishi T, Nakanishi H, Shimanaka Y, Kono N, Shinmura K, Arai H, Fukuda K and Sano M, Sirt1 counteracts decrease in membrane phospholipid unsaturation and diastolic dysfunction during saturated fatty acid overload, J Mol Cell Cardiol. 2019 Aug;133:1-11. doi: 10.1016/j.yjmcc.2019.05.019. Epub 2019 May 27.

  • Kusunoki H, Iwashima Y, Kawano Y, Hayashi SI, Kishida M, Horio T, Shinmura K and Yoshihara F, Association Between Circadian Hemodynamic Characteristics and Target Organ Damage in Patients With Essential Hypertension, Am J Hypertens. 2019 Jul 17;32(8):742-751. doi: 10.1093/ajh/hpz088.

  • Hasegawa Y, Sakuramoto A, Sugita H, Hasegawa K, Horii N, Sawada T, Shinmura K and Kishimoto H, Relationship between oral environment and frailty among older adults dwelling in a rural Japanese community: a cross-sectional observational study, BMC Oral Health. 2019 Jan 22;19(1):23. doi: 10.1186/s12903-019-0714-8.

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